Design of a Phase 2b Trial of Intracoronary Administration of AAV1/SERCA2a in Patients With Advanced Heart Failure
نویسندگان
چکیده
Design of a Phase 2b Trial of Intracoronary Administration of AAV1/SERCA2a in Patients With Advanced Heart Failure The CUPID 2 Trial (Calcium Up-Regulation by Percutaneous Administration of Gene Therapy in Cardiac Disease Phase 2b) Barry Greenberg, MD,* Alex Yaroshinsky, PHD,y Krisztina M. Zsebo, PHD,z Javed Butler, MD, MPH,x G. Michael Felker, MD,k Adriaan A. Voors, MD,{ Jeffrey J. Rudy, BS,z Kim Wagner, MA,z Roger J. Hajjar, MD#
منابع مشابه
Long-term effects of AAV1/SERCA2a gene transfer in patients with severe heart failure: analysis of recurrent cardiovascular events and mortality.
RATIONALE The Calcium Up-Regulation by Percutaneous Administration of Gene Therapy In Cardiac Disease (CUPID 1) study was a phase 1/phase 2 first-in-human clinical gene therapy trial using an adeno-associated virus serotype 1 (AAV1) vector carrying the sarcoplasmic reticulum calcium ATPase gene (AAV1/SERCA2a) in patients with advanced heart failure. The study explored potential benefits of the ...
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